Since the inclusion of Aloe in the first United States Pharmacopoeia in 1820, numerous investigators have studied its efficacy within a wide range of clinical applications.
1935 — Collins and Collins first describe Aloe Vera in the treatment and healing of a 31 year-old woman suffering from radio-dermatitis, a very difficult condition to treat.
1936 — Wright describes the use of Aloe in the treatment of radiation ulcers.
1940 — Row and associates note that Aloe helps heal burns faster than any other treatment available.
1945 — Russian academician V. P. Filatov reports effective treatment of skin conditions caused by parasites.
1950-70 — Studies showing Aloe’s effectiveness in healing radiation, burns and frostbite continues, showing further evidence of improved wound healing in radiation dermatitis and ulcers. K. Somova in Russia and E. Zimmerman in the U.S. separately show treatment of periodontal disease with Aloe; Blitz and Smith use Aloe in the treatment of 18 patients with peptic ulcer disease, with 17 of 18 patients recovering from symptoms.
During the last two decades, numerous researchers have shed extensive light on the beneficial properties of Aloe in the treatment of various health-related issues.
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1980 — Wolfe shows Aloe to be highly effective against various microorganisms including staph, strep, candida and even in relieving pain and irritation of herpes.
1980 — Heggers and Robson show Aloe to be an effective treatment of thermal injury in dogs.
1982 — Heggers confirms the presence of salicylic acid, an aspirin-like compound in Aloe, explaining the plant’s anti-inflammatory and pain relieving properties.
1985 — Heggers and Robson demonstrate the improved healing in thermal wounds due to the anti-prostaglandin activity of Aloe.
1986 — Ghanam shows anti-diabetic activity of Aloe and its effectiveness in lowering blood glucose levels in diabetic mice. This was confirmed later in human patients at the King Saud University in Saudi Arabia.
1987 — Burns describes how the sap of Aloe leaves decreases pain and increases healing in Herpes Zoster blister breakouts.
1988 — Fulton shows faster healing of full-face dermabrasion patients when treated with Aloe Vera.
1992 — Robson and Heggers show increased wound healing in rats with burn injuries when treated with Aloe.
1994 — Davis suggests that mannose sugars in Aloe contribute to increased wound healing.
1994 — Robson, Heggers and Winters show increased wound breaking strength in wounds treated with Aloe and silver sulfadiazine.
1995 — Miller and Koltai show increased tissue survival in frostbite injury when treated with Aloe Vera.
1996 — Robson and Heggers show accelerated wound contraction, increased collagen activity and enhanced breaking strength of wounds treated with Aloe.